Taylors Fire Battalion Chief Ricky Reed told the Greenville News that the accident happened 2pm Saturday at a church carnival near Greenville.
The incident injured five children; two of the children were seriously injured after they fell from the house to the ground.
Springwell Church invites the community to attend its free spring carnival each year, but this year the carnival ended in tears, with church members asking for prayer. A witness to the incident reportedly said that she was there to help the children out of the inflatable once it touched ground again.
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A witness said the bouncy house was anchored down with stakes and straps. The power lines weren't live when they went down, he added.
Emergency officials told local media outlets that the bounce house may have flown as high as 30 feet before hitting the power line, and that the children inside were extremely fortunate the inflatable did not catch fire as a result.
"It's kind of like, you know, like in the desert, where they have one of those dust storms", Reed said.
"It was very chaotic when we first arrived just because of the sheer number of people and everybody being upset", Reed said. "Shortly after 2 p.m., an unexpected wind gust, out of our control, lifted an inflatable amusement that was on our campus for the event".