Travis Shaw went 3 for 4 with a homer and three RBIs for Milwaukee.
The Chicago Cubs will look to build on their win on Tuesday that snapped a 4-game losing skid.
Wade Davis (2-0) worked around a walk in the ninth.
Dylan Covey (0-1) got knocked around in his second major league start, allowing eight runs, 10 hits and three homers over five innings.
All the Cubs needed in that situation was a base hit, but Russell came through with a no-doubt-about-it three-run homer into a very strong wind blowing out off Neftali Feliz.
Thames also scored three runs, and Bandy also had three hits. Who are these Cubs one road trip, one homestand and 15 games into their title defense?
April the giraffe's baby is already taller than Tom Cruise
People around the world have been tuning in daily, with some growing impatient as the pregnancy seemed to drag on. April the giraffe gave birth at a NY zoo as more than a million people around the world watched live .
His heroics capped a four-run ninth that came on the heels of a single run in the eighth as the Cubs rallied from a 4-2 deficit. La Stella was batting 1-for-4 with an RBI double and two walks over six games.
Milwaukee Brewers' Orlando Arcia smiles after scoring on a RBI single hit by Jonathan Villar off Chicago Cubs starting pitcher Kyle Hendricks during the fourth inning of a baseball game, Wednesday, April 19, 2017, in Chicago. In the ninth, Jon Jay drew a walk and pinch-hitter Miguel Montero followed with a single for his sixth hit in three games to set up the winning rally.
Astros 5, Angels 1 • Josh Reddick homered, tripled and doubled to propel host Houston, which got seven solid innings on the mound from Dallas Keuchel. He tied the Milwaukee record held by Jeromy Burnitz (1997) with home runs in five consecutive games.
Nationals 3, Braves 1: Max Scherzer allowed two hits over seven shutout innings as Washington handed Atlanta its first loss in its new Sun Trust Park. The Pirates put up a five-spot in the inning, capped off by a two-run blast hit by Andrew McCutchen off of Pedro Strop.
YANKEES 9, WHITE SOX 1: Aaron Judge hit a long homer and Masahiro Tanaka pitched seven innings of one-run ball as NY wrapped up a superb homestand.
Phillies 6, Mets 2 (10 innings): Cameron Rupp scored the tying run in the eighth inning and lofted the go-ahead sacrifice fly during a four-run 10th inning as Philadelphia defeated NY.