The former Southampton manager praised his players effort and performance, despite Tottenham leaving Old Trafford empty handed: "The effort was fantastic".
"It was our mistake", said the Spurs manager, clearly disappointed with the way his team failed to handle a straightforward long ball forward from United keeper David De Gea.
Though he would no doubt rather have Kane fit and firing against United, Pochettino may be encouraged by the fact that Tottenham have not lost a match when the 24-year-old hasn't played in over three years.
Kane has been Spurs' main man this season, scoring eight goals in 9 appearances. We are waiting, maybe he surprise us today or next week. I always believe we can win with one or another team, with one or another player. Pochettino, who will be without star striker Harry Kane for the clash against United, hinted that Lamela is not mentally over his injury woes just yet, and is waiting for his compatriot to let him know when he can play again.
"I would be very disappointed if his words were different", Mourinho said.
"Yes, you always want all the players available". But, like always, we beleive in the collective, in the squad and during the season sometimes these things happen. "It happens during a season, you can not play well all the time, you can not win all the time".
As expected, Harry Kane has been left out of the Spurs starting XI as he is carrying a minor injury. Pochettino said it was only a "small issue" but he did not want to exacerbate the problem by playing him against United.
"He needs two, three, four, five or six matches in a row to play, to make mistakes, to get conditioned, to get match fitness and I can not give him that". The players are not machines and it's hard to cope with worldwide duty and to play every three days. "It's lucky it's not a big problem but he's not going to play tomorrow".
Pochettino could hand summer signing Llorente his full Premier League debut in place of Kane, while utilising Son an out-and-out striker is also a possibility.
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He said the exercises were routine and not directly linked to any worldwide developments, the Associated Press reported. Earlier this month, Russian Federation conducted exercises involving intercontinental ballistic missile launchers.
Mourinho will be looking for his players to show a considerable improvement on their attitude to the one they displayed against Huddersfield.
"It's hard to explain", he said. It may seem odd to suggest that any problem for Tottenham is not good news for the Gunners, but I have a frightful feeling it could turn out to be that way.
Poor league form - plus an early exit in the League Cup - has left them already 12 points adrift of leaders Manchester City.
"It was a very, very, very competitive game", he added. I think nobody should forget this.
"You can't win every game but we need to analyse this and make sure we learn from it".
"It will be a big statement if we beat them".
Asked if the loss of Kane will force him into a change of system, Pochettino said: "Today is the second day after West Ham game so it's hard".
"United have one day more rest, an advantage, to prepare".