Sale (1-0) allowed a single run on eight hits while striking out eight batters through six innings to collect his first win of the season during Tuesday's 14-1 victory over the Yankees.
Kahnle surrendered two more before Chasen Shreve took over and gave up a grand slam to Mookie Betts that hiked the lead to 14-1.
Here are five takeaways from the blowout.
Chris Sale was dominant. Miami was led by Justin Bour, who hit a pair of two-run homers, both to the opposite field.
Cardinals 5, Brewers 3 (11 innings): Matt Carpenter cracked a two-run homer in the bottom of the 11th inning as St. Louis outlasted visiting Milwaukee.
Sale also overmatched Gary Sanchez, inducing a groundout and a pop-up - and striking him out swinging with a nasty slider that broke across the plate and landed behind the Yankee catcher.
Before that, it got quite ugly for the Yankees slugger.
On Tuesday night, they were not wrong. The 116.3-mph blast was the hardest home run ever hit off the Red Sox ace. Eleven games into the season the Yankees already trail the AL East-leading Red Sox by 4 ½ lengths.
West Ham winger Michail Antonio out rest of season with hamstring injury
The Hammers last won at Stamford Bridge in September 2002 when Paolo Di Canio's late goal clinched a 3-2 victory. Chelsea head into the match having lost three of their last four fixtures in the top flight.
Versus the Yankees, Betts became the first Red Sox player in club history with at least four hits, four runs scored and four runs batted in from the leadoff post.
Betts battled a sore wrist through most of previous year, but he's completely healthy and locked in to start the season.
He is the first Red Sox pitcher in the last 100 years with seven-plus scoreless innings pitched and four or fewer hits allowed in each of his first two starts of a season. The Red Sox won the division with 93 wins, but the young Yankees got the attention.
Nationals 4, Braves 1: Stephen Strasburg threw eight scoreless innings, and Ryan Zimmerman hit a two-run triple in the first to give Washington all the offense it needed to defeat visiting Atlanta.
Padres 5, Rockies 2: Hunter Renfroe broke a tie with a three-run, two-out homer in the seventh, and rookie left-hander Joey Lucchesi didn't allow an earned run over six-plus innings to earn his first major league win as visiting San Diego defeated Colorado. Severino previously worked with Hall of Famer and Red Sox legend Pedro Martinez to avoid tipping pitches and attempted to make his delivery more deceptive.
"I don't know if I was tipping or if they saw something, but the game is not the time to be working on it", Severino said. "I need to maybe go to the bullpen or see video, and see what's going on".
Severino went 2-1 with a 3.33 ERA in four starts against Boston last season. Since homering twice on Opening Day in Toronto, Stanton was batting.108 (4-for-37) with a homer, three RBIs, 19 strikeouts and a.449 OPS. "To go out there and get 21 outs and not give up a run".