Sadly for the home fans, who had created a deafening din in the opening minutes, Akinfeev inexplicably vacated his bottom left corner, moving back to the side of the goal his wall was guarding and leaving space for Suarez to stroke the ball home.
Sitting safely on their seventh successive clean sheet, Uruguay pushed for a third late on but Cavani's attempts to get on the scoresheet were initially fruitless, slicing a 20-yard shot horribly wide from a chance he created himself.
Uruguay - Muslera 6, Coates 6, Godin 7, Caceres 6, Torreira 8, Nandez 6, Vecino 7, Bentancur 7, Laxalt 7, Suarez 7, Cavani 7.
It all went wrong for the hosts and, while they still comfortably progress to the last 16, the consequences of this defeat will become apparent further down the line.
Twice World Cup winners Uruguay offered them the chance to show they truly belonged among the elite, but it was an opportunity wasted.
Russia, who had sealed their spot for the last 16 before the match, will have the consolation of a day's extra rest and huge support at Moscow's Luzhniki Stadium when they face the Group B winners on Sunday.
[World Cup Roundup] Uruguay Qualifies for Last-16, Spain, Portugal Win
In Game two, Nigeria plays Iceland in Group D in a very important match for the African team, as they were beaten 2-0 by Croatia . Need more? Since the first World Cup in 1930, the tournament has had more than 1,150 matches played by thousands of players.
Meanwhile, the Uruguayan machine, so well oiled by Oscar Tabarez even after making four changes to the team that beat the Saudis, delivered a lesson in efficient attacking football, with battling Rodrigo Betancur orchestrating their fluid game. "We are preparing for this game exactly the same way", he said at the press conference.
Cherchesov also says that Russian football players rode roughshod over the beginning of such hard matches as the one against Uruguay was. Our medical team will also advise us.
Because Russia had the advantage on goal difference from its first two group matches, it would have won the group with a draw.
Alan Dzagoev is still sidelined after picking up a hamstring injury against Saudi Arabia, although his replacement Denis Cheryshev has scored three goals in two matches.
Match no 34 between Uruguay vs Russian Federation is scheduled to take place on June 25, Monday at 7.30 pm IST. By finishing second, Russian Federation will play at the Luzhniki Stadium in Moscow against the Group A victor.
They had spluttered in defeating Egypt and Saudi Arabia 1-0 but came out of the traps quickly vs. Russian Federation. Both Spain and Portugal had a goal difference of plus-1, but Spain scored six goals in its three group matches while Portugal had five.